FabRICATOR® References

Åkesson, P et al. IdeS, a highly specific immunoglobulin G (IgG)-cleaving enzyme from Streptococcus pyogenes, is inhibited by specific IgG antibodies generated during infection; Infection and Immunity: 497-503, 2006. [PubMed]

Hess, J., L et al. Immunoglobulin clevage by the streptococcal cysteine proteinase IdeS can be detected using protein G capturing and mass spectrometry; J. Microbiol. Meth.: 70, 284-291, 2007. [PubMed]

Ryan, M., H et al. Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid; Mol. Immunology: 45, 1837-1846, 2008. [PubMed]

von Pawel-Rammingen, U et al. IdeS, a novel streptoccocal cysteine proteinase with unique specificity for immunoglobulin G; The EMBO Journal: 21, 1607-1615, 2002. [PubMed]

Vincents, B et al. Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine proteinase with strict specificity for IgG cleveage due to exosite binding; Biochemistry: 43, 15540-15549, 2004. [PubMed]

Wenig, K et al. Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG; PNAS: 101, 17371-17376, 2004. [PubMed]