FeOlabel and FeOdot Nanoparticles

Coated Iron Core Particles for Cellular Uptake and Imaging

FeOdots: Tiny spheres – Big uses

FeOdots are 20–40 nm superparamagnetic particles with high magnetic susceptibility. Depending on the intended use, the particles can be coated with various surface molecules. The basic iron oxide cores are coated with a modified-PEG surface that promotes particle stability and solubility in many common buffers at physiological pHs and ionic strengths.  FeOdots are also compatible with extremes in pH and ionic strength, showing no flocculation over extended periods of time – making them ideal for a myriad of unique uses.  The modified-PEG coating has active amine groups that canserve as an effective anchor for further derivatizations and/or conjugation with fluorescent markers, enzymes, antibodies or affinity tags.  If you are looking for something a bit different, we also offer custom FeOdots of consistently high quality and stability in a wide range of iron oxide core sizes and specialty coatings – for example primary amines, PEG, or biotin.

FeOlabel: Optimized for cellular uptake in vitro and ex vivo

FeOlabel products are based on the inherent property that superparamagnetic iron oxide nanoparticles can be easily seen by magnetic resonance imaging (MRI).  Long-lasting, sensitive, and low-toxicity labeling is achieved by formulating our basic FeOdot particles with an outer coating that facilitates delivery into living cells. More than 95% of cells are transfected with FeOlabel within a few minutes, and allow for long-term, ex vivo, detection via MRI for several weeks without bleaching. Intracellular labeling with magnetic particles also enables cell sorting using magnetic cell separation with lab magnets and high gradient magnetic field columns. We supply fluorescently labeled magnetic nanoparticles, providing researchers with the option for dual detection. Intracellular magnetic labeling of cells has never been easier – just add the FeOlabel to your cells and incubate. No more elaborate work with transfection agents to get sufficient labeling for MRI visualization.