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New reagents for fragmenting IgGs

Hello from Bulldog Bio!

 

You may be a first time receiver of our newsletter - The Barker.  We understand the value of your time, and so we only wish to present unique opportunities for improving the quality of your research experience.  Thanks for taking time to read more about our new line of antibody-engineering tools.

Best in Show - FabRICATOR® IgG Protease

 

The novel FabRICATOR protease specifically cleaves the Fc domain from many types of IgG molecules resulting in pure F(ab')2 fragments, with no further degradation.  Not only is the site specific to the hinge region, but the yield is quite incredible, with over 95% of all IgG molecules cut in 30 minutes.  And when it is time to purify the F(ab')2 fragments, our FabRICATOR F(ab')2 Purification Kit does the job quickly and efficiently by combining the cutting power of FabRICATOR protease with magnetic bead separation technology.  Go from milligram quantities of IgG to milligrams of F(ab')2 in under 1 hour. Click here to request a sample.

 

Advantages

  • Specific cleavage of Fc domain from IgG
  • Simpler to use than Papain or other proteases
  • Efficient cutting in under 30 min
  • Ultrapure F(ab')2 in under 1 hr
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    Throw Me a Bone

    If you are ordering any of our Antibody Tools products for the first time, we will include a case of 1000 Aloetouch ICE Nitrile Lab Gloves for free.  Just reference the following promotional code in your order: BTB002.  Your hands will thank you!


    Win a free bobble head in K9 Logic below!

     

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    It's a Dog's Life-

    "real lab experience with our products"

     

    FabRICATOR protease, a cysteine proteinase, cuts IgGs more effectively than other proteases.  Also known as the streptococcal endopeptidase, IdeS, this enzyme has evolved a strict specificity for the IgG hinge region and is used in nature to down regulate immune responses against the bacterium.  Numerous recent publications attest to its specific cleaving action and efficiency. 

    K-9 Logic

     

    Every quarter we give away 30 scientist bobble heads to subscribers to The Barker that can answer a riddle or logic problem. If you know the answer to this month's challenge, click here to submit your answer and have a chance to win a free Pillars of Science bobble head.

     

    In honor of our newest addition to our Pillars of Science collection, Charles Darwin, we will pose a scientific twist on a classic riddle that he might have appreciated, tongue-in-cheek. 

    Below is a sequence of 12 letters, derived from a very simple relationship, in which the first three letters have been ommitted. In earlier days, this may have been used as an intellengence test in English-speaking schools:

     

    _ _ _ F F S S E N T E T

     

    What are the first three letters?