PURPLE NIMT®
Transfection Reagent

Nanoparticle-based siRNA Delivery

Gentle enough for tough transfections

PURPLE is a new transfection agent for siRNA delivery based on lipid-coated iron oxide nanoparticles. These particles consist of solid iron oxide cores that are enveloped with a specific cationic lipid formulation to facilitate siRNA binding and cellular uptake. This unique technology reduces cell toxicity, in part, by using small amounts of siRNA to help counter off-target effects. When using PURPLE, effective gene silencing is reached in a wide range of cell lines including suspension cells, mesenchymal stem cells as well as adherent cell lines.

* PURPLE will be discountinued on Sept. 1st, 2010

Very fast and very efficient

PURPLE is easy to use. Simply mix particles and siRNA, incubate 15-20 min at room temperature and then add to cells. Next incubate the cells for 8-48 hrs and then analyze knockdown effect. Not only is the protocol simple, PURPLE can provide ultra-high efficiencies, and in a fraction of the time of standard transfection methodologies. And did we mention that PURPLE also provides an economical solution for higher density plate types?